Dulaglutide 5mg – GLP-1R Agonism & IgG4-Fc Fusion Protein Kinetics Research

Description

What is Dulaglutide & CAS 923950-08-7?

Dulaglutide, identified by the CAS number 923950-08-7, is a potent, long-acting glucagon-like peptide-1 (GLP-1) receptor agonist. Unlike short-lived native GLP-1, Dulaglutide is engineered by linking two identical GLP-1 analogues to a modified human immunoglobulin G4 (IgG4) heavy chain fragment. This unique molecular structure significantly extends its half-life, making it a primary subject for research into sustained metabolic regulation.

At 99Purity-Peptide, we provide Dulaglutide as a high-stability, sterile lyophilized powder. It is specifically produced for laboratory researchers investigating glucose-dependent insulin secretion, gastric emptying rates, and long-term weight management pathways in biological models.

Dulaglutide (CAS 923950-08-7) Mechanism of Action and Research

Dulaglutide functions as a GLP-1 receptor agonist, activating the same pathways as the natural incretin hormone. Its primary research applications include stimulating insulin secretion in a glucose-dependent manner, suppressing glucagon secretion, and slowing gastric emptying. In research models, it is studied for its ability to promote satiety and reduce caloric intake through its interaction with the central nervous system.

Dosage in Research Studies

Quantitative data on Dulaglutide is derived from preclinical trials and comparative metabolic studies. In animal models, the observed dosage was often calibrated between 0.1 mg/kg and 0.6 mg/kg administered once weekly via subcutaneous injection, depending on the specific research focus on glycemic control versus weight reduction.

Citation: Research published in The Lancet and comparative studies by Barrington et al. (2011) highlight that Dulaglutide’s fusion protein structure allows for high potency with a prolonged duration of action, observing significant improvements in HbA1c levels and body mass index in chronic metabolic models. (Source: Barrington, P., et al. “A 5-week study of the pharmacokinetics and pharmacodynamics of dulaglutide, a novel GLP-1 receptor agonist.” Diabetes, Obesity and Metabolism, 2011).

Trending Research Topics & High-Authority Links:

• GLP-1 vs. GIP/GLP-1 Dual Agonists: Exploring the comparative efficacy of Dulaglutide and Tirzepatide.

• Cardiovascular Outcomes in GLP-1 Research: Long-term metabolic protection studies.

• Pharmacodynamics of Dulaglutide in metabolic research – PubMed

Dulaglutide Specifications

Feature	Specification
Product Name	Dulaglutide
Available Strengths	5mg, 10mg
Physical Appearance	White Lyophilized Powder
Purity	≥ 99% (HPLC/MS Tested)
Molecular Formula	C2646H4044N704O836S18
Molecular Weight	~59.7 kDa (Dimer)
CAS Number	923950-08-7
Verification	3rd-Party HPLC & COA Available
Storage Instructions	-20°C for long-term; 2-8°C after reconstitution

Dulaglutide Key Features & Benefits

• Extended Metabolic Research: Designed for the study of long-acting GLP-1 receptor activation and sustained satiety.

• Weight Management Relevance: Investigated for its impact on adipose tissue reduction and caloric intake regulation.

• High-Purity Preparation: Synthesized at 99%+ purity to ensure the integrity of laboratory experimental data.

• Sterile Lyophilized Format: Vacuum-sealed for maximum stability, ensuring the peptide remains potent during global transit.

• Independently Verified: Every batch is tested via HPLC to confirm chemical identity and purity levels.

Dulaglutide Research FAQ

What is the half-life of Dulaglutide in research?

Due to its IgG4 Fc fusion structure, Dulaglutide has a research-observed half-life of approximately 5 days, allowing for once-weekly administration protocols in most biological studies.

How should Dulaglutide be stored?

The lyophilized powder should be stored at -20°C. Once reconstituted with bacteriostatic water, it should be kept refrigerated at 2-8°C and used within a specific experimental timeframe (typically 14 days) to maintain potency.

Does Dulaglutide require third-party testing?

Yes. At 99Purity-Peptide, we provide a Certificate of Analysis (COA) for every order, ensuring the 99% purity standard is met for professional research use.

Why Buy Dulaglutide online from 99Purity-Peptide?

• Scientific Grade Consistency: We specialize in high-purity peptides for researchers who demand reproducible results.

• Secure & Discreet Handling: All orders are shipped in neutral, secure packaging to protect your research privacy and ensure safe arrival.

• Support for Global Transactions: We accept Credit Cards, PayPal, and Cryptocurrencies (USDT, USDC) for your convenience.

• Reliable Fulfillment: Orders are processed and dispatched within 1-2 business days, with full tracking provided for the USA, UK, and Europe.

Payment Support & Logistics

• Secure Payment Options: We support multiple secure gateways, including Credit Cards, Cryptocurrency (USDT, USDC), PayPal, and Bank Transfers.

• Global Shipping: Fast, tracked delivery available to the United States, United Kingdom, and Europe.

• Processing Time: All orders are professionally handled and dispatched within 1-2 business days after payment confirmation.

Regulatory Disclaimer

99Purity-Peptide is a chemical supplier. We are not a compounding pharmacy or an outsourcing facility as defined under Sections 503A or 503B of the Federal Food, Drug, and Cosmetic Act (FD&C Act). All products are strictly for research, laboratory, or analytical use only and are NOT for human consumption.

References & Academic Links

• Barrington, P., et al. (2011). “A 5-week study of the pharmacokinetics and pharmacodynamics of dulaglutide.” Diabetes, Obesity and Metabolism.

• Glaesner, W., et al. (2010). “Engineering and characterization of the long-acting GLP-1 analogue dulaglutide.” Diabetes/Metabolism Research and Reviews.

• Nauck, M., et al. (2014). “Dulaglutide versus sitagliptin in patients with type 2 diabetes.” The Lancet.