ACE-031 Peptide (Ramatercept) 1mg – ActRIIB Ligand Traps & TGF-β Signaling Research

Description

What is ACE-031 (Ramatercept) & CAS 1160561-31-0?

In the evolving field of musculoskeletal science, ACE-031, scientifically recognized as Ramatercept (CAS 1160561-31-0), stands out as a soluble fusion protein. It is a recombinant therapeutic composed of the extracellular portion of the activin receptor type IIB (ActRIIB) fused to the Fc portion of human IgG1. This peptide is engineered specifically for research into biological growth factors that govern muscle mass. By acting as a “decoy” receptor, ACE-031 is primarily investigated for its potential to prevent specific signaling molecules from restricting muscle growth, making it a cornerstone for studies focusing on muscle wasting diseases and physical performance enhancement.

Our ACE-031 1mg vials are produced as a sterile, vacuum-sealed lyophilized powder to ensure the highest stability. This advanced freeze-drying process protects the protein’s complex structure from degradation during transit and storage. At 99Purity-Peptide, we provide researchers with high-purity ACE-031 that is consistently verified for its molecular weight and sequence, ensuring that your laboratory results are both accurate and reproducible.

ACE-031 (Ramatercept) Mechanism of Action and Research

Regarding the biological pathways of muscle regulation, ACE-031 functions by binding to and neutralizing ligands such as myostatin (GDF-8) and activin A. In a laboratory environment, these ligands normally bind to the ActRIIB receptor on the surface of muscle cells to signal the cessation of muscle growth. By introducing ACE-031 into a research model, the decoy receptor intercepts these ligands before they can reach the cell surface. This mechanism effectively “shuts off” the inhibitory signal, allowing for the investigation of accelerated skeletal muscle hypertrophy and increased lean mass.

Advancing the understanding of physical performance and degenerative conditions, contemporary studies utilize ACE-031 to evaluate its efficacy in preserving muscle mass during states of atrophy. Emerging data from high-fidelity laboratory trials suggests that ACE-031 may also influence bone density and fat metabolism, as the ActRIIB pathway is involved in systemic metabolic regulation. Its role in bypassing the natural genetic “ceiling” of muscle development makes it a primary subject for research into neuromuscular disorders and age-related sarcopenia.

Trending Research Topics & High-Authority Insights:

• ActRIIB Signaling and Muscle Hypertrophy: Investigating the blockade of inhibitory growth factors.

• Myostatin Inhibition in Neuromuscular Research: The future of treating muscle-wasting pathologies.

• ACE-031 and its impact on skeletal muscle mass preservation – PubMed

ACE-031 (Ramatercept) Specifications

Feature	Specification
Product Name	ACE-031 (Ramatercept)
Available Strengths	1mg
Physical Appearance	White Lyophilized Powder
Purity	≥ 99% (HPLC/MS Verified)
Verification Method	3rd-Party Lab Tested with COA
Storage Instructions	Store at -20°C (Long-term); 2-8°C after reconstitution
Molecular Weight	~110 kDa (Fusion Protein)
CAS Number	1160561-31-0

ACE-031 Key Features & Benefits

• Advanced Myostatin Antagonist: Specifically designed to study the inhibition of GDF-8 and other muscle-limiting proteins.

• Skeletal Muscle Growth Subject: Optimized for research related to muscle hypertrophy, strength gain, and bone density preservation.

• High-Purity Protein Preparation: Synthesized at 99%+ purity to ensure clean experimental data in growth factor signaling studies.

• Lyophilized for Peak Stability: Vacuum-sealed sterile powder offers an extended shelf life and resists thermal degradation.

• Independently Lab-Verified: Every batch undergoes HPLC and Mass Spectrometry testing to confirm identity and bio-activity.

ACE-031 (Ramatercept) FAQ

How does ACE-031 differ from Follistatin in muscle research?

While both are researched for myostatin inhibition, ACE-031 is a soluble ActRIIB receptor analog. Researchers often prefer ACE-031 for its broader inhibitory profile, as it can bind to a wider range of ligands (like Activin A and B) compared to Follistatin, allowing for a more comprehensive study of muscle-growth signaling pathways.

Why is ACE-031 provided in a 1mg vial strength?

ACE-031 is a highly potent fusion protein. In laboratory settings, 1mg is a standard concentration for dose-response studies. Providing it in this strength ensures that researchers can manage precise dilutions while maintaining the stability of the lyophilized cake until the moment of reconstitution.

What is the recommended storage protocol for ACE-031?

To maintain 99% purity, the lyophilized powder should be stored in a freezer at -20°C. Once reconstituted with sterile bacteriostatic water, the solution should be kept refrigerated at 2-8°C and used within a short timeframe to avoid protein denaturation.

Is ACE-031 currently being researched for bone health?

Yes. Because the ActRIIB receptor also interacts with ligands that affect bone remodeling, ACE-031 is a subject of interest in studies focusing on increasing bone mineral density and the dual-action recovery of muscle and bone tissues after injury.

Why Buy ACE-031 online from 99Purity-Peptide?

• Uncompromising Quality Control: We prioritize chemical precision for performance research, ensuring every vial of ACE-031 meets a 99%+ purity benchmark.

• Consistent Batch Performance: Our manufacturing protocols ensure that the protein sequence and folding remain identical across all batches, supporting credible longitudinal results.

• Secure and Professional Shipping: We understand the sensitivity of growth factor research. All orders are shipped in unbranded, secure packaging with temperature-stable precautions where necessary.

• Trusted Logistics for Researchers: With 1-2 business day dispatch and tracking provided for the USA, UK, and Europe, we ensure your lab supplies arrive when you need them.

Payment Support & Logistics

• Secure Payment Options: We support multiple secure gateways, including Credit Cards, Cryptocurrency (USDT, USDC), PayPal, and Bank Transfers.

• Global Shipping: Fast, tracked delivery available to the United States, United Kingdom, and Europe.

• Processing Time: All orders are professionally handled and dispatched within 1-2 business days after payment confirmation.

Regulatory Disclaimer

99Purity-Peptide is a chemical supplier. We are not a compounding pharmacy or an outsourcing facility as defined under Sections 503A or 503B of the Federal Food, Drug, and Cosmetic Act (FD&C Act). All products are strictly for research, laboratory, or analytical use only and are NOT for human consumption.

References & Academic Links

• Attie, K. M., et al. (2013). “A single ascending-dose study of ACE-031 in healthy volunteers.” Muscle & Nerve.

• Campbell, C., et al. (2017). “Activin receptor type IIB inhibition and skeletal muscle mass.” ScienceDirect – Metabolic Signaling.

• Wagner, K. R. (2008). “The growth factor signaling pathway in muscle wasting.” PubMed – Current Opinion in Rheumatology.