LL-37 Peptide 5mg – Host Defense Signaling & Innate Immunity Research

Description

What is LL-37 Peptide & CAS 154948-66-3?

From a pharmacological perspective, LL-37 (CAS 154948-66-3) is the only representative of the cathelicidin family of antimicrobial peptides found in humans. It is a 37-amino acid, amphipathic alpha-helical peptide cleaved from the C-terminal of the hCAP18 protein. Primarily expressed in neutrophils and epithelial cells, LL-37 is engineered for research into the body’s first line of defense. Unlike traditional antibiotics, LL-37 is studied for its dual role: acting directly against pathogens while simultaneously functioning as a potent signaling molecule for tissue repair, angiogenesis, and immune cell recruitment.

Driven by the demand for high-fidelity clinical-grade materials, our LL-37 Peptide 5mg is supplied as a vacuum-sealed, lyophilized powder. This sophisticated freeze-drying process is vital for maintaining the complex 37-amino acid sequence, protecting it from the proteolytic degradation that often compromises liquid formulations. At 99Purity-Peptide, we ensure that the structural integrity of this human-derived cathelicidin remains consistent, providing an ideal medium for longitudinal studies on wound closure and chronic inflammatory signaling.

LL-37 Peptide Mechanism of Action and Research

Within the landscape of innate immunity research, LL-37 functions by disrupting the cell membranes of bacteria, fungi, and certain viruses through its cationic properties. However, its laboratory utility extends far beyond its antimicrobial nature. In a laboratory environment, scientists have observed that LL-37 binds to the FPR2 (Formyl Peptide Receptor 2), triggering the migration of keratinocytes and endothelial cells to the site of injury. By leveraging these properties, researchers are investigating how LL-37 accelerates the re-epithelialization of skin and promotes the formation of new blood vessels in ischemic tissues.

Advancing the understanding of complex wound healing, contemporary studies utilize LL-37 to evaluate its impact on “biofilm” disruption and immune system modulation. Emerging data from high-fidelity laboratory trials suggests that LL-37 can neutralize lipopolysaccharides (LPS), thereby reducing the risk of systemic inflammatory cascades. Its multifaceted role in balancing pro-inflammatory and anti-inflammatory signals makes LL-37 a foundational pillar for research into diabetic foot ulcers, chronic surgical wounds, and systemic autoimmune defense mechanisms.

Trending Research Topics & High-Authority Insights:

• Cathelicidin-Mediated Wound Healing: Investigating keratinocyte migration pathways.

• Biofilm Disruption Research: The role of LL-37 in combating antibiotic-resistant strains.

• The role of LL-37 in human innate immunity and tissue repair – ScienceDirect

LL-37 Peptide Specifications

Feature	Specification
Product Name	LL-37 (Human Cathelicidin)
Available Strengths	5mg
Physical Appearance	White Lyophilized Powder
Purity	≥ 99% (HPLC/MS Verified)
Verification Method	3rd-Party Lab Tested with COA
Storage Instructions	Store at -20°C (Long-term); 2-8°C after reconstitution
Molecular Formula	$C_{205}H_{340}N_{60}O_{53}$
Molecular Weight	4493.33 g/mol
CAS Number	154948-66-3

LL-37 Peptide Key Features & Benefits

• Premier Antimicrobial Subject: Specifically researched for its ability to target multi-drug resistant bacteria and biofilm structures.

• Wound Healing Accelerator: Optimized for studies involving re-epithelialization, skin repair, and keratinocyte proliferation.

• Immune Response Modulator: A foundational molecule for research into FPR2 receptor activation and cytokine regulation.

• High-Purity Preparation: Synthesized at 99%+ purity to eliminate experimental noise in complex immunological models.

• Independently Verified Identity: Each batch is confirmed via HPLC and Mass Spectrometry for absolute amino acid sequence accuracy.

LL-37 Peptide FAQ

How does LL-37 differ from standard antimicrobial peptides?

While many peptides are strictly bactericidal, LL-37 is “pleiotropic.” Researchers value LL-37 because it combines antimicrobial action with the ability to signal for cell growth and angiogenesis. This makes it a superior subject for studying “difficult-to-heal” tissue environments where both infection and poor circulation are factors.

Why is the 5mg lyophilized format used for LL-37 research?

Due to its length (37 amino acids), LL-37 is more susceptible to degradation than smaller tripeptides. The 5mg lyophilized format ensures the peptide remains stable during transit. It allows researchers to reconstitute small, fresh batches, which is essential for maintaining bio-activity in delicate cell culture assays.

What is the recommended reconstitution protocol for LL-37 5mg?

To achieve reproducible data, LL-37 should be reconstituted using sterile bacteriostatic water or a specific buffer (like PBS) depending on the research model. The liquid should be added slowly to the vial wall. Avoid shaking; use a slow swirling motion to ensure the 5mg of powder dissolves without denaturing the helical structure.

Is LL-37 being researched for respiratory health?

Yes. Contemporary research explores LL-37’s presence in the airway surface liquid. Scientists utilize our high-purity vials to investigate how this peptide protects lung tissue from pathogens and modulates the inflammatory response in pulmonary research models.

Why Buy LL-37 online from 99Purity-Peptide?

• Scientific Grade Consistency: We prioritize the chemical precision required for high-stakes immune research, ensuring every vial of LL-37 meets our 99%+ purity benchmark.

• Reliable Batch-to-Batch Quality: Our manufacturing protocols ensure that the bio-activity and peptide sequence of our LL-37 remain identical in every vial, supporting credible long-term results.

• Discreet & Tracked Logistics: Your research privacy is a priority. All orders feature unbranded, secure packaging with expedited tracked shipping to the USA, UK, and Europe.

• Total Consumer Protection: From 3rd-party lab verification (COA) to 1-2 business day dispatch, we provide the professional reliability that modern biotechnology researchers demand.

Payment Support & Logistics

• Secure Payment Options: We support multiple secure gateways, including Credit Cards, Cryptocurrency (USDT, USDC), PayPal, and Bank Transfers.

• Global Shipping: Fast, tracked delivery available to the United States, United Kingdom, and Europe.

• Processing Time: All orders are professionally handled and dispatched within 1-2 business days after payment confirmation.

Regulatory Disclaimer

99Purity-Peptide is a chemical supplier. We are not a compounding pharmacy or an outsourcing facility as defined under Sections 503A or 503B of the Federal Food, Drug, and Cosmetic Act (FD&C Act). All products are strictly for research, laboratory, or analytical use only and are NOT for human consumption.

References & Academic Links

• Vandamme, D., et al. (2012). “LL-37: The multifunctional human cathelicidin peptide.” PubMed – Peptides.

• Koczulla, R., et al. (2003). “An angiogenic role for the human peptide antibiotic LL-37.” ScienceDirect – Journal of Clinical Investigation.

• Heilborn, J. D., et al. (2003). “The cathelicidin anti-microbial peptide LL-37 is involved in re-epithelialization of human skin wounds.” Journal of Investigative Dermatology.

• Durr, U. H., et al. (2006). “LL-37, the only human member of the cathelicidin family of antimicrobial peptides.” Project Topaz – Molecular Research.