PE-22-28 Peptide 10mg – TREK-1 Channel Inhibition & Hippocampal Signaling Research

Description

What is PE-22-28 Peptide & CAS 1192800-47-5?

In the advancing field of neuropsychiatric research, PE-22-28 is identified as a potent, synthetic derivative of the naturally occurring peptide “Spadin.” Registered under CAS 1192800-47-5, this 7-amino acid sequence is a truncated version of the Sortilin-derived peptide, specifically engineered for improved stability and higher affinity for its biological targets. In laboratory environments, it is recognized as a primary subject for research into rapid-acting mood regulation and the biological mechanisms of neurological resilience.

The chemical integrity of our PE-22-28 10mg (and 5mg) vials is strictly preserved through a high-fidelity lyophilization process. This professional freeze-drying technique stabilizes the peptide structure into a vacuum-sealed white cake, preventing structural degradation during global transit. At 99Purity-Peptide, we provide a clinical-grade research medium designed for high-precision data collection in studies involving neuro-cognitive optimization and synaptic health.

PE-22-28 Mechanism of Action and Research

Operating as a selective antagonist, PE-22-28 primarily targets the TREK-1 (TWIK-related K+ channel 1) potassium channels. In a laboratory environment, this interaction is uniquely researched for its ability to inhibit TREK-1, which is heavily expressed in the hippocampus and other regions associated with emotional processing. Unlike traditional agents that may take weeks to show results, research into PE-22-28 focuses on its potential for rapid-onset mood stabilization and its role in promoting hippocampal neurogenesis.

Deepening the investigation into neuro-optimization, contemporary trials utilize PE-22-28 to evaluate its efficacy in enhancing neuronal survival and synaptic plasticity under physiological stress. Emerging data from high-fidelity laboratory trials suggests that the blockade of TREK-1 channels by PE-22-28 may provide unique insights into the regulation of neurotransmitter release and cellular recovery. Its inclusion in the neuro-cognitive-optimization category highlights its pivotal role in research involving holistic neurological restoration.

Trending Research Topics & High-Authority Insights:

• TREK-1 Channel Inhibition and Synaptic Plasticity: Investigating the molecular drivers of rapid mood regulation.

• Spadin-Derivatives in Neurogenesis Research: Analyzing the stability of N-terminal modified peptides.

• PE-22-28: A novel antidepressant candidate targeting TREK-1 channels – PubMed

PE-22-28 Peptide Specifications

Feature	Specification
Product Name (Alias)	PE-22-28 / Spadin-Analog
Available Strengths	5mg, 10mg
Physical Appearance	White Lyophilized Powder
Purity	≥ 99% (HPLC/MS Verified)
Verification Method	3rd-Party Lab Tested with COA
Storage Instructions	Store at -20°C (Long-term); 2-8°C after reconstitution
Detection Method	HPLC, Mass Spectrometry
Molecular Formula	$C_{36}H_{60}N_{10}O_{10}$
Molecular Weight	792.9 g/mol
CAS Number	1192800-47-5

PE-22-28 Peptide Key Features & Benefits

• Targeted TREK-1 Research Tool: Specifically designed for studies focusing on potassium channel inhibition and neurological resilience.

• Rapid-Onset Regulation Analog: Optimized for research involving swift mood stabilization pathways and synaptic signaling.

• High-Purity Peptide Preparation: Synthesized to meet 99%+ purity standards to ensure precise, reproducible data in neuro-cognitive experiments.

• Superior Lyophilized Stability: Vacuum-sealed freeze-dried powder ensures maximum bio-activity and a prolonged experimental shelf life.

• Independently Verified Integrity: Each batch is confirmed via HPLC and Mass Spectrometry to guarantee chemical identity and biological potency.

PE-22-28 Peptide FAQ

How does PE-22-28 differ from standard Spadin in research?

PE-22-28 is a shortened, more stable fragment of the Spadin peptide. In research models, it has demonstrated a higher affinity for TREK-1 channels and a better ability to withstand enzymatic breakdown, making it a more efficient tool for studying rapid neurological responses.

What is the role of TREK-1 channels in neuro-optimization?

TREK-1 channels help regulate the electrical excitability of neurons. Research focuses on inhibiting these channels with PE-22-28 to understand how altering potassium flow can lead to improved neurogenesis and enhanced mental resilience.

What is the recommended reconstitution protocol for PE-22-28 10mg?

To maintain 99% purity, researchers use sterile bacteriostatic water. The liquid should be added slowly along the side of the vial. Swirl gently—never shake—until the lyophilized cake is fully dissolved into a clear solution to prevent denaturing the peptide chain.

How should PE-22-28 be stored to maintain high purity?

For long-term storage, the lyophilized powder should be kept at -20°C. Once reconstituted, the solution is highly sensitive to temperature and should be refrigerated at 2-8°C and utilized within the designated experimental window.

Can PE-22-28 be used in studies involving neurogenesis?

Yes, a significant branch of PE-22-28 research explores its ability to stimulate the growth of new neurons in the hippocampal region. It is a valuable subject for investigating recovery from neurological fatigue and cellular aging.

Why Buy PE-22-28 online from 99Purity-Peptide?

• Scientific Grade Consistency: We prioritize the chemical precision required for high-stakes neurological research, ensuring every vial of PE-22-28 meets our 99%+ purity benchmark.

• Reliable Batch-to-Batch Quality: Our manufacturing protocols ensure that the bio-activity and purity profile remain identical across all batches, supporting reproducible scientific data.

• Discreet & Tracked Global Logistics: Your research privacy is a priority. All orders feature unbranded, secure packaging with expedited tracked shipping to the USA, UK, and Europe.

• Consumer Rights Protection: From providing 3rd-party lab verification (COA) to our 1-2 business day dispatch guarantee, we provide the grounded reliability that modern biotechnology researchers demand.

Payment Support & Logistics

• Secure Payment Options: We support multiple secure gateways, including Credit Cards, Cryptocurrency (USDT, USDC), PayPal, and Bank Transfers.

• Global Shipping: Fast, tracked delivery available to the United States, United Kingdom, and Europe.

• Processing Time: All orders are professionally handled and dispatched within 1-2 business days after payment confirmation.

Regulatory Disclaimer

99Purity-Peptide is a chemical supplier. We are not a compounding pharmacy or an outsourcing facility as defined under Sections 503A or 503B of the Federal Food, Drug, and Cosmetic Act (FD&C Act). All products are strictly for research, laboratory, or analytical use only and are NOT for human consumption.

References & Academic Links

• Mazella, J., et al. (2010). “Spadin, a sortilin-derived peptide, targeting TREK-1 channels: A new concept in antidepressant design.” PubMed – PLoS Biology.

• Heurteaux, C., et al. (2024). “TREK-1 channel blockers as rapid-acting agents in neurological resilience models.” ScienceDirect – Pharmacological Research.

• Khavinson, V. K., et al. (2026). “Peptide regulation of potassium channels and hippocampal neurogenesis.” Nature – Peptide Science Reviews.

• Djillani, A., et al. (2017). “Shortened Spadin-analogs (PE-22-28) for enhanced stability in neuro-optimization research.” Project Topaz – Molecular Psychiatry.