FOX04-DRI Peptide 10mg – Research into p53 Interaction & Senescent Cell Apoptosis

Description

What is FOX04-DRI & The Senescence Intervention?

The study of cellular longevity has been revolutionized by the development of “senolytic” agents. FOX04-DRI (D-Retro-Inverso) is a cell-permeable peptide designed specifically to interfere with the interaction between the FOXO4 transcription factor and the p53 tumor suppressor protein. In healthy cells, p53 regulates DNA repair or apoptosis; however, in “zombie” or senescent cells, FOXO4 sequesters p53, preventing it from inducing programmed cell death. FOX04-DRI acts as a decoy to break this bond, allowing the cell to finally undergo apoptosis.

Ensuring the precise molecular geometry of D-amino acids is critical for the efficacy of this peptide. To support high-stakes longevity research, we provide FOX04-DRI 10mg and 2mg in a vacuum-sealed, lyophilized state. This specific D-Retro-Inverso configuration is significantly more resistant to proteolytic degradation than standard L-peptides, offering researchers a highly stable and potent tool for investigating tissue regeneration and the clearance of senescent cell populations.

FOX04-DRI Mechanism of Action and Research

Characterized by its unique ability to induce targeted apoptosis, FOX04-DRI is a focal point of research into the “Senolytic” clearance of aging cells. By competing with endogenous FOXO4 for p53 binding, the peptide effectively releases p53 to move into the mitochondria and trigger the apoptotic signaling pathway. In laboratory aging models, this selective clearance has been observed to lead to improvements in fur density, renal function, and overall physiological frailty, making it a premier candidate for studies on systemic rejuvenation.

Researchers currently utilize FOX04-DRI to explore the reversal of age-related organ dysfunction. Beyond its role in clearing non-dividing cells, scientific investigations are looking into how the removal of the Senescence-Associated Secretory Phenotype (SASP)—the toxic inflammatory cocktail secreted by aging cells—can restore the regenerative capacity of surrounding healthy stem cells. Its role in modulating the microenvironment of the tissue matrix makes it a vital subject for contemporary gerontology.

Trending Research Topics & High-Authority Insights:

• Selective Senolysis and p53 Signaling: Investigating the targeted elimination of damaged cells.

• SASP Modulation in Aging Models: The impact of cell clearance on systemic inflammation.

• FOXO4-p53 Interfering Peptide Reverses Age-Related Phenotypes – ScienceDirect

FOX04-DRI Specifications

Feature	Specification
Product Name	FOX04-DRI (D-Retro-Inverso Peptide)
Available Strengths	2mg, 10mg
Physical Appearance	White Lyophilized Powder
Purity	≥ 99% (HPLC/MS Verified)
Molecular Formula	$C_{212}H_{345}N_{65}O_{62}S_{2}$
Molecular Weight	4804.42 g/mol
CAS Number	N/A (Research Grade Peptide)
Verification Method	3rd-Party Lab Tested with COA
Storage Instructions	Store at -20°C (Long-term); 2-8°C after reconstitution

FOX04-DRI Key Features & Benefits

• Advanced Senolytic Agent: Specifically researched for its ability to clear senescent cells via p53-FOXO4 interference.

• D-Retro-Inverso Stability: Engineered for increased resistance to enzymatic breakdown and enhanced biological half-life.

• High-Purity Rejuvenation Formula: Synthesized at 99%+ purity to ensure minimal off-target effects in laboratory models.

• Sterile Freeze-Dried Stability: Vacuum-sealed to maintain the integrity of the long-chain peptide during global shipping.

• Independently Verified Accuracy: Every batch is confirmed via HPLC and Mass Spectrometry to guarantee the exact amino acid sequence.

FOX04-DRI Research FAQ

What does “DRI” stand for in FOX04-DRI?

DRI stands for D-Retro-Inverso. This means the peptide is made with D-amino acids in a reversed sequence. In research, this is used to create a “mirror image” of the original peptide that is much harder for the body’s enzymes to break down, allowing for longer study durations in vivo.

How does FOX04-DRI differentiate between healthy and senescent cells?

The peptide targets the specific over-expression of the FOXO4-p53 bond found in senescent cells. While healthy cells use p53 for normal DNA repair, only senescent cells rely on FOXO4 to “hide” p53. FOX04-DRI exposes this hiding spot only in those damaged cells.

Why is the 10mg vial recommended for tissue rejuvenation studies?

Systemic clearance studies in laboratory models often require precise, consistent dosing over several weeks. The 10mg strength provides the necessary concentration to ensure that the experimental parameters remain consistent across multiple tissue samples or research subjects.

What is the proper way to reconstitute FOX04-DRI?

Due to its complex molecular weight, researchers should use sterile bacteriostatic water or saline. The liquid should be added slowly, and the vial should be swirled very gently. Shaking can damage the long peptide chain, compromising the accuracy of your research data.

Why Buy FOX04-DRI online from 99Purity-Peptide?

• Pioneering Senolytic Synthesis: We specialize in the difficult production of DRI peptides, ensuring that your research utilizes a 99%+ pure medium for valid and reproducible results.

• Discreet & Tracked Logistics: Your research privacy is a priority. All orders feature unbranded, secure packaging with expedited tracked shipping to the USA, UK, and Europe.

• Reliable Batch Consistency: Our manufacturing protocols ensure that the chemical profile and folding of our FOX04-DRI remain identical batch-after-batch.

• Total Transparency: From 3rd-party lab verification (COA) to 1-2 business day dispatch, we provide the professional reliability that modern biotechnology researchers demand.

Payment Support & Logistics

• Secure Payment Options: We support multiple secure gateways, including Credit Cards, Cryptocurrency (USDT, USDC), PayPal, and Bank Transfers.

• Global Shipping: Fast, tracked delivery available to the United States, United Kingdom, and Europe.

• Processing Time: All orders are professionally handled and dispatched within 1-2 business days after payment confirmation.

Regulatory Disclaimer

99Purity-Peptide is a chemical supplier. We are not a compounding pharmacy or an outsourcing facility as defined under Sections 503A or 503B of the Federal Food, Drug, and Cosmetic Act (FD&C Act). All products are strictly for research, laboratory, or analytical use only and are NOT for human consumption.

References & Academic Links

• Baar, M. P., et al. (2017). “Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging.” Cell.

• Zhang, L., et al. (2020). “Senolytic drugs: from discovery to translation.” Journal of Internal Medicine.

• Khavinson, V. K., et al. (2019). “Peptide regulation of gene expression and aging.” Project Topaz – Gerontology Research Archives.