Mazdutide 10mg – GLP-1R & GCGR Dual Agonism for Metabolic Homeostasis Research

Description

What is Mazdutide & CAS 2459634-11-2?

Mazdutide (also known by its developmental code IBI362) is a next-generation synthetic oxyntomodulin analogue. Identified by the CAS number 2459634-11-2, it represents a major breakthrough in metabolic research as a dual agonist. Unlike traditional single-target peptides, Mazdutide is engineered to activate both the glucagon-like peptide-1 receptor (GLP-1R) and the glucagon receptor (GCGR).

At 99Purity-Peptide, we supply Mazdutide as a high-purity lyophilized powder. This dual-targeting approach is currently the subject of intense study regarding its synergistic effects on energy expenditure, lipid metabolism, and sustained weight regulation in biological research models.

Mazdutide (CAS 2459634-11-2) Mechanism of Action and Research

The unique mechanism of Mazdutide lies in its dual-receptor activation. By stimulating the GLP-1 receptor, it promotes glucose-dependent insulin secretion and suppresses appetite. Simultaneously, its activation of the glucagon receptor mimics the effects of fasting or exercise, potentially increasing thermogenesis and energy expenditure. This dual-pathway interaction is hypothesized to provide superior metabolic regulation compared to single-agonist peptides.

In various research models, Mazdutide has demonstrated significant potential in reducing intrahepatic fat content and improving lipid profiles. Its structural optimization allows for a prolonged half-life, facilitating long-term longitudinal studies into the reversal of metabolic syndrome and obesity-related complications.

Trending Research Topics & High-Authority Insights:

• Dual-Agonism vs. Single-Agonism: The comparative efficacy of GLP-1/Glucagon dual agonists in metabolic research.

• Non-Alcoholic Fatty Liver Disease (NAFLD): Investigating the role of Mazdutide in liver fat reduction.

• Pharmacokinetics and pharmacodynamics of Mazdutide – PubMed

Mazdutide Specifications

Feature	Specification
Product Name	Mazdutide
Available Strengths	10mg
Physical Appearance	White Lyophilized Powder
Purity	≥ 99% (HPLC Verified)
Molecular Formula	$C_{211}H_{326}N_{52}O_{69}$
Molecular Weight	4683.19 g/mol
CAS Number	2459634-11-2
Verification	3rd-Party HPLC & COA Available
Storage Instructions	Store at -20°C (Long-term); 2-8°C after reconstitution

Mazdutide Key Features & Benefits

• Dual-Target Research Peptide: Simultaneously targets GLP-1R and GCGR for comprehensive metabolic studies.

• Advanced Weight Regulation Study: Investigated for its synergistic effects on satiety and basal metabolic rate.

• Pharmaceutical Grade Preparation: Synthesized at 99%+ purity to ensure experimental data remains uncontaminated and reproducible.

• Optimized Stability: Provided in a sterile, freeze-dried (lyophilized) state to maintain potency during global shipping and long-term storage.

• Independently Verified: Every batch is verified by HPLC and MS to confirm chemical identity and purity.

Mazdutide FAQ

How does Mazdutide differ from Semaglutide in research?

While Semaglutide is a selective GLP-1 receptor agonist, Mazdutide is a dual agonist that also targets the glucagon receptor. This additional target is studied for its ability to increase energy expenditure (calorie burning) in addition to suppressing appetite.

What is the purpose of the “Dual-Agonist” approach?

Researchers utilize dual agonists to study “synergistic” metabolic pathways. The goal is to observe if activating two receptors provides more profound results in fat mass reduction and glucose control than activating just one.

How should Mazdutide 10mg vials be handled?

The lyophilized powder should be stored at -20°C for maximum shelf life. When preparing for laboratory use, allow the vial to reach room temperature before reconstituting with bacteriostatic water.

Why is 99% purity critical for this specific peptide?

Because Mazdutide acts on two different receptors, even minor impurities can skew research data. 99Purity-Peptide ensures laboratory-grade standards to protect the integrity of your experimental outcomes.

Why Buy Mazdutide online from 99Purity-Peptide?

• Pioneering Product Consistency: We provide access to the latest metabolic research compounds with guaranteed consistency across every production cycle.

• Discreet Global Logistics: Your research privacy is our priority. We utilize neutral, secure packaging with expedited delivery to the USA, UK, and Europe.

• Professional Grade Standards: We bridge the gap between high-level research requirements and accessible supply, maintaining strict quality control for all our peptides.

• Customer-Centric Protections: From 3rd-party verification (COA) to transparent service, we ensure your investment in high-quality research materials is protected.

Payment Support & Logistics

• Secure Payment Options: We support multiple secure gateways, including Credit Cards, Cryptocurrency (USDT, USDC), PayPal, and Bank Transfers.

• Global Shipping: Fast, tracked delivery available to the United States, United Kingdom, and Europe.

• Processing Time: All orders are professionally handled and dispatched within 1-2 business days after payment confirmation.

Regulatory Disclaimer

99Purity-Peptide is a chemical supplier. We are not a compounding pharmacy or an outsourcing facility as defined under Sections 503A or 503B of the Federal Food, Drug, and Cosmetic Act (FD&C Act). All products are strictly for research, laboratory, or analytical use only and are NOT for human consumption.

References & Academic Links

• Ji, L., et al. (2022). “Efficacy and safety of Mazdutide in Chinese participants with overweight or obesity.” Nature Communications.

• Day, J. W., et al. (2009). “A new glucagon and GLP-1 co-agonist eliminates obesity in rodents.” Nature Chemical Biology.