Humanin 10mg – Mitochondrial Health & Neuro-Protection Research

Description

What is Humanin & CAS 330936-97-5?

Precision in cytoprotective research often centers on the mitochondrial genome’s hidden signaling potential. Humanin (CAS 330936-97-5) is a 24-amino acid peptide and the first discovered member of the mitochondrial-derived peptide (MDP) family. Unlike peptides encoded by the nuclear genome, Humanin is encoded within the 16S ribosomal RNA gene of the mitochondria. It acts as a retrograde signaling molecule, traveling from the mitochondria to the nucleus and extracellular space to modulate cell survival under conditions of metabolic or oxidative stress.

Characterized by its broad-spectrum anti-apoptotic activity, Humanin is provided by 99Purity-Peptide as a high-purity, white lyophilized powder. Delivering this peptide in a vacuum-sealed 10mg vial ensures that its complex 24-amino acid sequence maintains structural integrity. This professional-grade freeze-drying process protects the peptide from the enzymatic degradation and thermal instability that often affect liquid MDP preparations.

Humanin (CAS 330936-97-5) Mechanism of Action and Research

The research value of Humanin lies in its sophisticated dual-action mechanism. It functions both as an intracellular signaling molecule and an extracellular ligand. Internally, Humanin binds to pro-apoptotic proteins such as Bax, preventing their translocation to the mitochondria and thereby inhibiting the initiation of programmed cell death. Externally, it interacts with specific cell-surface receptors (including the CNTFR/gp130/WSX-1 complex) to activate JAK2/STAT3 signaling pathways, which promote cellular resilience and survival in the face of neurotoxic insults.

Scientific investigations currently utilize Humanin to explore the preservation of neuronal and vascular health. Researchers study its efficacy in neutralizing the toxic effects of Amyloid-beta plaques in laboratory models, as well as its role in improving insulin sensitivity and mitochondrial respiration. By acting as a “metabolic guardian,” Humanin has become a foundational subject for studies involving neurodegenerative disorders, cardiovascular protection, and the systemic deceleration of biological aging.

Trending Research Topics & High-Authority Insights:

• Mitochondrial Retrograde Signaling: Exploring how MDPs regulate nuclear gene expression.

• Cytoprotection in Metabolic Stress: The role of Humanin in preserving pancreatic and vascular cells.

• Humanin: A Novel Mitochondrial-Derived Peptide for Dermal and Neural Protection – PubMed

Humanin Specifications

Feature	Specification
Product Name	Humanin (MDP)
Available Strengths	10mg
Physical Appearance	White Lyophilized Powder
Purity	≥ 99% (HPLC/MS Verified)
Molecular Formula	$C_{119}H_{204}N_{34}O_{32}S_{2}$
Molecular Weight	2687.32 g/mol
CAS Number	330936-97-5
Verification Method	3rd-Party Lab Tested with COA
Storage Instructions	Store at -20°C (Long-term); 2-8°C after reconstitution

Humanin Key Features & Benefits

• Advanced Mitochondrial Signaling Subject: Specifically researched for its role as a retrograde messenger from the mitochondria.

• Broad-Spectrum Cytoprotectant: Targeted for studies on anti-apoptotic pathways and cellular survival under stress.

• High-Purity MDP Preparation: Synthesized at 99%+ purity to ensure experimental accuracy and eliminate secondary variables.

• Sterile Freeze-Dried Stability: Vacuum-sealed to resist environmental degradation and extend research shelf life.

• Independently Verified Identity: Each vial is confirmed via HPLC and Mass Spectrometry for absolute sequence fidelity.

Humanin Research FAQ

How does Humanin differ from other longevity peptides like Epithalon?

While Epithalon primarily focuses on telomerase activation and the “biological clock” of the nucleus, Humanin focuses on mitochondrial survival. Researchers often study them together to observe how nuclear and mitochondrial signaling pathways intersect to regulate systemic aging.

Why is the lyophilized form critical for Humanin research?

Humanin is a relatively long peptide (24 amino acids). Long-chain peptides are highly susceptible to “clipping” or unfolding if kept in liquid form at room temperature. Lyophilization locks the peptide in a stable “cake,” ensuring it remains bioactive until the exact moment of reconstitution.

What is the recommended reconstitution and storage protocol?

To maintain high-fidelity data, researchers typically use bacteriostatic water. After reconstitution, the vial should be stored at 2-8°C and protected from light. Because Humanin is a delicate MDP, avoid excessive agitation or vortexing, which can denature the peptide chain.

Is Humanin studied for neuro-protection specifically?

Yes. A significant portion of current research focuses on Humanin’s ability to protect neurons from various stressors. Laboratory models use our 10mg vials to investigate how this peptide might mitigate the cellular decline associated with neurodegenerative signaling.

Why Buy Humanin online from 99Purity-Peptide?

• Elite Biotechnology Quality: We specialize in the difficult synthesis of mitochondrial-derived peptides, ensuring your research is backed by a 99%+ pure medium for reproducible results.

• Reliable Batch-to-Batch Quality: Our manufacturing protocols ensure that the chemical profile and folding of our Humanin remain identical in every vial, supporting credible long-term research.

• Discreet & Tracked Logistics: Your research privacy is a priority. All orders are sent in neutral, secure packaging with expedited tracked shipping to the USA, UK, and Europe.

• Total Transparency: From 3rd-party lab verification (COA) to 1-2 business day dispatch, we provide the professional reliability that modern biotechnology researchers demand.

Payment Support & Logistics

• Secure Payment Options: We support multiple secure gateways, including Credit Cards, Cryptocurrency (USDT, USDC), PayPal, and Bank Transfers.

• Global Shipping: Fast, tracked delivery available to the United States, United Kingdom, and Europe.

• Processing Time: All orders are professionally handled and dispatched within 1-2 business days after payment confirmation.

Regulatory Disclaimer

99Purity-Peptide is a chemical supplier. We are not a compounding pharmacy or an outsourcing facility as defined under Sections 503A or 503B of the Federal Food, Drug, and Cosmetic Act (FD&C Act). All products are strictly for research, laboratory, or analytical use only and are NOT for human consumption.

References & Academic Links

• Hashimoto, Y., et al. (2001). “A rescue factor, Humanin, that protects against Alzheimer’s disease-relevant insults.” ScienceDirect – Biochemical and Biophysical Research Communications.

• Lee, C., et al. (2013). “The Mitochondrial-Derived Peptide Humanin Is a Potent Regulator of Metabolism.” Project Topaz – Aging Research Reviews.

• Gong, Z., et al. (2015). “Humanin: A cytoprotective peptide against oxidative stress and apoptosis.” PubMed – Cellular & Molecular Immunology.